| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-615 | |
| Phytochemical name or plant extracts | Erythro-austrobailignan-6 (EA6) | |
| PMID | 11731908 | |
| Literature evidence | Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. | |
| IUPAC name | 4-[(2R,3S)-4-(2H-1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol | |
| Phytochemicals’ class or type of plant extracts | Lignan | |
| Source of phytochemicals or plant Extracts | Machilus thunbergii | |
| Geographical availability | China North-Central, China Southeast, Japan, Korea, Nansei-shoto, Taiwan, Vietnam | |
| Plant parts | Bark | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | HER2/EGFR/integrinβ3, topo II | |
| Gene or Protein evidence | Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. At a concentration of 100 mM, 4 showed the strongest inhibitory activity on both DNA topoisomerases I and II and, as second and third effective inhibitors, 2 and 8 have selective inhibitory activity against DNA topoisomerase I activity compared to DNA topoisomerase II. Compound 2 is Erythro-austrobailignan-6 | |
| Target pathways | NA | |
| IC50 | 39.9 µM against MCF-7 | |
| Potency | Three of them, erythro-austrobailignan-6, meso-dihydroguaiaretic acid and nectandrin-B, exert an antiproliferative effect on MCF-7 cells as well as antioxidant activity on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, but not the threo-austrobailignan-5. | |
| Cell line/ mice model | MCF-7, 4T1 | |
| Additional information | NA | |
| PubChem ID | 10381847 | |
| Additional PMIDs | 15256759 11731908 28160858 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:466273-1 | |
| Safety | NA |