| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1099 | |
| Phytochemical name or plant extracts | Erucin | |
| PMID | 28958489 | |
| Literature evidence | ERN induced cell cycle arrest in the G2/M phase, down-regulated the phosphorylation of S6 ribosomal protein in all tested breast cancer cell lines, and reduced HER2 receptor levels in SKBR-3 cells. | |
| IUPAC name | 1-isothiocyanato-4-methylsulfanylbutane | |
| Phytochemicals’ class or type of plant extracts | Isothiocyanate | |
| Source of phytochemicals or plant Extracts | Eruca sativa | |
| Geographical availability | Afghanistan, Algeria, Baleares, China North-Central, China South-Central, China Southeast, Corse, Cyprus, East Aegean Is., Egypt, Greece, Gulf States, Inner Mongolia, Iran, Iraq, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Kuwait, Lebanon-Syria, Libya, Manchuria, Mongolia, Morocco, Oman, Pakistan, Palestine, Portugal, Qinghai, Sardegna, Saudi Arabia, Sicilia, Sinai, Spain, Tadzhikistan, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Uzbekistan, Xinjiang, Yemen | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | SOD1, ERK1, ERK2, Bax, Bcl-2, XIAP | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 28 µM against MCF-7 | |
| Potency | ERN effectively inhibits proliferation of breast cancer cells irrespectively of their receptor status. | |
| Cell line/ mice model | MDA-MB-231, SKBR-3, T47D, MCF-7 | |
| Additional information | In addition, erucin arrests cell cycle progression and induces apoptosis in human lung carcinoma, hepatoma and leukemia cell lines | |
| PubChem ID | 78160 | |
| Additional PMIDs | 26014809 26134366 27597660 28958489 25595902 12425469 24950293 23748931 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1110374-2 | |
| Safety | NA |