| Properties | Information |
|---|---|
| PhytoCAT-ID | PhytoCAT-1616 |
| Phytochemical name or plant extracts | Eriocitrin |
| PMID | 34724282 |
| Literature evidence | From this evidence, Eriocitrin, a novel chemotherapeutic agent, can be used to treat breast cancer. © 2021 Wiley Periodicals LLC. |
| IUPAC name | (2S)-2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one |
| Phytochemicals’ class or type of plant extracts | Flavonoid |
| Source of phytochemicals or plant Extracts | NA |
| Geographical availability | NA |
| Plant parts | NA |
| Other cancers | Breast cancer |
| Target gene or protein | STAT-3, Bcl-2 |
| Gene or Protein evidence | Eriocitrin induced apoptosis via suppression of STAT3 signaling regulated proteins, activating proapoptotic factors Bax, caspase 7, 8, 9 and suppressing Bcl-2, Bcl-x expression in MCF-7 cells. |
| Target pathways | Eriocitrin, a dietary flavonoid suppressed cell proliferation, induced apoptosis through modulation of JAK2/STAT3 and JNK/p38 MAPKs signaling pathway in MCF-7 cells..Eriocitrin suppressed STAT3 phosphorylation via inhibiting an upstream molecule of JAK2 and Src kinase activation, thereby blocking STAT3 nuclear translocation. |
| IC50 | NA |
| Potency | Overall, these results evidenced that Eriocitrin can affect multiple signaling events associated with tumorigenesis. From this evidence, Eriocitrin, a novel chemotherapeutic agent, can be used to treat breast cancer. |
| Cell line/ mice model | MCF-7 |
| Additional information | We confirmed that Eriocitrin induced ROS-mediated apoptosis inhibited by the antioxidant substance of N-acetylcysteine. |
| PubChem ID | 83489 |
| Additional PMIDs | NA |
| Additional sources of information | NA |
| Safety | NA |