| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-384 | |
| Phytochemical name or plant extracts | Eriocalyxin B | |
| PMID | 28669564 | |
| Literature evidence | We found that EriB was able to induce apoptosis accompanied by the activation of autophagy, which was evidenced by the increased accumulation of autophagosomes, acidic vesicular organelles formation, the microtubule-associated protein 1A/1B-light chain 3B-II (LC3B-II) conversion from LC3B-I and p62 degradation. | |
| IUPAC name | (1S,2S,5R,8S,9S,10S,11R)-9,10-dihydroxy-12,12-dimethyl-6-methylidene-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadec-13-ene-7,15-dione | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Isodon eriocalyx | |
| Geographical availability | China South-Central, China Southeast, Myanmar, Thailand | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NF-κBp65, STAT-3 , Bax, Bcl-2, MMP, Caspase 3 | |
| Gene or Protein evidence | EriB induced apoptosis in MDA-MB231 cells via inhibiting NF-ϰBp65, STAT3 phosphorylation, increasing Bax/Bcl-2 ratio, MMP dissipation, and activation of caspase-3. | |
| Target pathways | Akt/mTOR/p70S6K signaling pathway | |
| IC50 | NA | |
| Potency | Taken together, our findings firstly demonstrated that EriB suppressed breast cancer cells growth both in vitro and in vivo, and thus could be developed as a promising anti-breast tumor agent. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 / MDA-MB-231 xenograft model | |
| Additional information | nterestingly, the autophagic features and apoptosis induction were prevented by reactive oxygen species (ROS) scavenger N-acetyl-l-cysteine, indicating that ROS played an essential role in the mediation of EriB-induced cell death. | |
| PubChem ID | 16202215 | |
| Additional PMIDs | 32024623 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:448573-1 | |
| Safety | NA |