| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-653 | |
| Phytochemical name or plant extracts | Erianin | |
| PMID | 33385512 | |
| Literature evidence | The study presented a novel strategy for the treatment of breast cancer. | |
| IUPAC name | 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol | |
| Phytochemicals’ class or type of plant extracts | Bibenzyl | |
| Source of phytochemicals or plant Extracts | Dendrobium nobile | |
| Geographical availability | Assam, Bangladesh, China South-Central, China Southeast, East Himalaya, Hainan, India, Laos, Myanmar, Nepal, Thailand, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2 | |
| Gene or Protein evidence | Erianin induced apoptosis in T47D cells through reducing Bcl-2 expression and activating caspase signaling. | |
| Target pathways | ERK pathways, JNK pathways or mitochondrial apoptosis pathways | |
| IC50 | NA | |
| Potency | Together, these results demonstrated that Erianin might have the potential to be an effective drug to treat the ER positive breast cancer. | |
| Cell line/ mice model | T47D, MDA-MB-231, MCF-7 | |
| Additional information | In addition, Erianin treatment suppressed the migration of T47D cells, most likely through regulating the homeostatic expression of MPP and TIMP. | |
| PubChem ID | 356759 | |
| Additional PMIDs | 27508028 33385512 34408399 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:60456844-2 | |
| Safety | Meanwhile, Erianin did not affect the proliferation of normal breast epithelial cell line MCF10A. |