| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-348 | |
| Phytochemical name or plant extracts | Epunctanone | |
| PMID | 30195869 | |
| Literature evidence | Flow cytometry was used for cell cycle analysis in CCRF-CEM cells treated with compound 5, as well as detection of apoptotic cells by annexin V/PI staining, analysis of mitochondrial membrane potential (MMP) and measurement of reactive oxygen species (ROS). | |
| IUPAC name | (1S,3S,9R,11S)-7-(3,4-dihydroxybenzoyl)-4,4,10,10-tetramethyl-3,9-bis(3-methylbut-2-enyl)-11-(3-methylbutyl)-5-oxatricyclo[7.3.1.01,6]tridec-6-ene-8,13-dione | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Garcinia epunctata | |
| Geographical availability | Angola, Cabinda, Cameroon, Central African Repu, Congo, Equatorial Guinea, Gabon, Ghana, Ivory Coast, Liberia, Nigeria, Sierra Leone, Zaïre | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Leukemia, colon cancer, Liver cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 5.88 ± 0.62 against MDA-MB-231 BCRP | |
| Potency | Compounds 1-5 are valuable cytotoxic compounds that could be used to combat MDR cancer cells. Benzophenoe 5 is the most active molecule and deserve more investigations to develop new anticancer drugs. Compound 5 is Epunctanone | |
| Cell line/ mice model | MDA-MB-231, HCT116CEM/ADR5000, MDA-MB-231-BCRP,HCT116 (p53-/-),U87MG | |
| Additional information | Meanwhile, pre-treatment of cells with two ferroptosis inhibitors (ferrostain-1 and deferoxamine) greatly reduced the cytotoxicity of epunctanone over CCRF-CEM leukemia cells. | |
| PubChem ID | 163184065 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:427945-1. https://doi.org/10.3390/ph15111360 | |
| Safety | NA |