Properties | Information | |
---|---|---|
PhytoCAT-ID | PhytoCAT-1338 | |
Phytochemical name or plant extracts | Epoxyazadiradione | |
PMID | 22277739 | |
Literature evidence | Cedrelone (13) and dysobinin (18) showed significant cytotoxicity, and toonayunnanin B (2) and epoxyazadiradione (14), were found to be slightly cytotoxic against the above cell lines. | |
IUPAC name | [(1S,2R,4S,6S,7S,10R,11R,16R,18R)-6-(furan-3-yl)-1,7,11,15,15-pentamethyl-5,14-dioxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadec-12-en-18-yl] acetate | |
Phytochemicals’ class or type of plant extracts | Triterpenoid | |
Source of phytochemicals or plant Extracts | Toona ciliata, Neem | |
Geographical availability | Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Pakistan, Philippines, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya Alaska, Albania, Alberta, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Central European Rus, China North-Central, Chita, Colorado, Connecticut, Corse, Czechoslovakia, Delaware, Denmark, East European Russia, Finland, Florida, France, Georgia, Germany, Great Britain, Greece, Hungary, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Iran, Ireland, Irkutsk, Italy, Japan, Kansas, Kazakhstan, Khabarovsk, Kirgizstan, Krasnoyarsk, Labrador, Maine, Manitoba, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Mongolia, Montana, Nebraska, Netherlands, New Hampshire, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Ohio, Oklahoma, Ontario, Oregon, Pennsylvania, Poland, Portugal, Primorye, Prince Edward I., Québec, Rhode I., Romania, Sardegna, Sicilia, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Texas, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, Vermont, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yugoslavia, Yukon | |
Plant parts | Leaves | |
Other cancers | Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer | |
Target gene or protein | MMP9 | |
Gene or Protein evidence | Downregulation of MMP-9 | |
Target pathways | NF-kappaB pathway | |
IC50 | NA | |
Potency | NA | |
Cell line/ mice model | HL-60, SMMC-7721, A-549, MCF-7, SW480, MDA-MB-231 | |
Additional information | Induces mitochondria-mediated apoptosis and anoikis in TNBC cells (MDA-MB-231), promotes antimigration, inhibition of colony formation, downregulation of MMP-9 and fibronectin, induction of G2/M phase arrest with downregulation of cyclin A2/cdk2, interference in cellular metabolism, and inhibition of nuclear factor kappa-B (NF-kB) nuclear translocation. | |
PubChem ID | 49863985 | |
Additional PMIDs | 33684251 | |
Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:579299-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458280-1 | |
Safety | NA |