Phytochemical Name : Epoxyazadiradione

Properties Information
PhytoCAT-ID PhytoCAT-1338
Phytochemical name or plant extracts Epoxyazadiradione
PMID 22277739
Literature evidence Cedrelone (13) and dysobinin (18) showed significant cytotoxicity, and toonayunnanin B (2) and epoxyazadiradione (14), were found to be slightly cytotoxic against the above cell lines.
IUPAC name [(1S,2R,4S,6S,7S,10R,11R,16R,18R)-6-(furan-3-yl)-1,7,11,15,15-pentamethyl-5,14-dioxo-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadec-12-en-18-yl] acetate
Phytochemicals’ class or type of plant extracts Triterpenoid
Source of phytochemicals or plant Extracts Toona ciliata, Neem
Geographical availability Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Myanmar, Nepal, New Guinea, Pakistan, Philippines, Sulawesi, Sumatera, Thailand, Vietnam, West Himalaya Alaska, Albania, Alberta, Altay, Amur, Arizona, Austria, Baltic States, Belarus, Belgium, British Columbia, Bulgaria, Buryatiya, California, Central European Rus, China North-Central, Chita, Colorado, Connecticut, Corse, Czechoslovakia, Delaware, Denmark, East European Russia, Finland, Florida, France, Georgia, Germany, Great Britain, Greece, Hungary, Idaho, Illinois, Indiana, Inner Mongolia, Iowa, Iran, Ireland, Irkutsk, Italy, Japan, Kansas, Kazakhstan, Khabarovsk, Kirgizstan, Krasnoyarsk, Labrador, Maine, Manitoba, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Mongolia, Montana, Nebraska, Netherlands, New Hampshire, New Jersey, New Mexico, New York, Newfoundland, North Carolina, North Caucasus, North Dakota, North European Russi, Northwest European R, Northwest Territorie, Norway, Nova Scotia, Ohio, Oklahoma, Ontario, Oregon, Pennsylvania, Poland, Portugal, Primorye, Prince Edward I., Québec, Rhode I., Romania, Sardegna, Sicilia, South Dakota, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Texas, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, Vermont, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Wyoming, Xinjiang, Yakutskiya, Yugoslavia, Yukon
Plant parts Leaves
Other cancers Breast cancer, Leukemia, Liver cancer, Lung cancer, Colon cancer
Target gene or protein MMP9
Gene or Protein evidence Downregulation of MMP-9
Target pathways NF-kappaB pathway
IC50 NA
Potency NA
Cell line/ mice model HL-60, SMMC-7721, A-549, MCF-7, SW480, MDA-MB-231
Additional information  Induces mitochondria-mediated apoptosis and anoikis in TNBC cells (MDA-MB-231), promotes antimigration, inhibition of colony formation, downregulation of MMP-9 and fibronectin, induction of G2/M phase arrest with downregulation of cyclin A2/cdk2, interference in cellular metabolism, and inhibition of nuclear factor kappa-B (NF-kB) nuclear translocation.
PubChem ID 49863985
Additional PMIDs 33684251
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:579299-1 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:458280-1
Safety NA