| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1195 | |
| Phytochemical name or plant extracts | Epoxy clerodane diterpene (ECD) | |
| PMID | 28068628 | |
| Literature evidence | Diterpene possesses multiple bioactivities, here, epoxy clerodane diterpene (ECD) was isolated from Tinospora cordifolia (Willd.) stem and shown potential antiproliferative effect in MCF-7 human breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Tinospora cordifolia | |
| Geographical availability | Andaman Is., Assam, Bangladesh, East Himalaya, India, Maldives, Myanmar, Nicobar Is., Sri Lanka, Vietnam | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Caspase 3, Caspase 8, Caspase 9, p21, Bcl-2, mdm2, PCNA | |
| Gene or Protein evidence | In addition, we observed that ECD treatment significantly (p ≤0.001) upregulated the expression of apoptotic genes such as Bax, cas-3, cas-8, cas-9 and p21 and downregulated the expression of BCL-2, mdm2 and PCNA. | |
| Target pathways | In conclusion, ECD regulates the expression of Cdkn2A, p53 and mdm2 and induces apoptosis via the mitochondrial pathway in MCF-7 human breast cancer cells. | |
| IC50 | 3.2 μM against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | In conclusion, ECD regulates the expression of Cdkn2A, p53 and mdm2 and induces apoptosis via the mitochondrial pathway in MCF-7 human breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:907828-1 | |
| Safety | NA |