| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1373 | |
| Phytochemical name or plant extracts | Epipremnum pinnatum extract | |
| PMID | 15619555 | |
| Literature evidence | Epipremnum pinnatum (L.) Engl. hexane extract produced a significant growth inhibition against T-47D breast carcinoma cells and analysis of cell death mechanisms indicated that the extract elicited a non-apoptotic programmed cell death. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Hexane extract | |
| Source of phytochemicals or plant Extracts | Epipremnum pinnatum | |
| Geographical availability | Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, Cook Is., Fiji, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Maluku, Marshall Is., Myanmar, Nansei-shoto, New Caledonia, New Guinea, Nicobar Is., Northern Territory, Philippines, Queensland, Samoa, Santa Cruz Is., Solomon Is., Sulawesi, Sumatera, Taiwan, Thailand, Tonga, Vanuatu, Vietnam, Wallis-Futuna Is. | |
| Plant parts | Leaves and stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, p53, c-myc | |
| Gene or Protein evidence | In addition, acute exposure to the extract produced an insignificant regulation of caspase-3 and p53 mRNA expression but increased in the c-myc mRNA expression. | |
| Target pathways | c-myc pathway | |
| IC50 | NA | |
| Potency | T-47D: EC50 - 1.20g/ml (48h), 2.90 g/ml (72h) | |
| Cell line/ mice model | T-47D | |
| Additional information | These findings suggested that up-regulation of c-myc mRNA expression may have contributed to the growth arrest and Type II non-apoptotic programmed cell death in the Epipremnum pinnatum (L.) Engl. hexane extract-treated T-47D cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:87046-1 | |
| Safety | NA |