| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1578 | |
| Phytochemical name or plant extracts | Epimedium brevicornum extract | |
| PMID | 17628368 | |
| Literature evidence | The Chinese medicinal herb, Epimedium, used traditionally for bone health exerts estrogenic activity (EA) in vitro. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Epimedium brevicornum | |
| Geographical availability | NA | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERalpha, Progesteron receptor | |
| Gene or Protein evidence | Oral administration of Epimedium brevicornum increased ERalpha activity (1320EA(ERalpha) min, p<0.01). A genetically characterized Epimedium brevicornum (EB) extract induced biphasic responses in the mRNA and protein expression of the estrogen-regulated progesterone receptor gene in breast cancer (MCF-7) cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In male Sprague-Dawley rats, administration of the estrogenic prodrug, estradiol valerate increased area-under-curve of serum effects for ERalpha (AUC difference: 18,900EA(ERalpha) min, 95% CI: 0-37,800, p = 0.05) and breast cancer cell (MCF-7) growth (AUC difference: 30,200EA(MCF-7) min, 95% CI: 24,200-36,200, p<0.001), compared to placebo. Oral administration of Epimedium brevicornum increased ERalpha activity (1320EA(ERalpha) min, p<0.01). Our data indicate that estrogen-responsive bioassays can measure the pharmacokinetic/pharmacodynamics of estrogenic activity in serum. Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Epimedium brevicornum extract increases estrogenic activity in serum and human studies are required to evaluate whether Epimedium extracts have utility for estrogen replacement therapy. | |
| PubChem ID | NA | |
| Additional PMIDs | 15729618 24310211 29338226 | |
| Additional sources of information | NA | |
| Safety | NA |