| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1024 | |
| Phytochemical name or plant extracts | Epigallocatechin gallate (EGCG) | |
| PMID | 28930270 | |
| Literature evidence | RESULTS: Only quercetin, curcumin and EGCG showed significant protective effects against leptin-induced proliferation of MCF-7 cells. | |
| IUPAC name | [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Catechin | |
| Source of phytochemicals or plant Extracts | Limoniastrum guyonianum | |
| Geographical availability | Algeria, Egypt, Libya, Tunisia | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer, Colorectal cancer, Stomach cancer, Prostate cancer, esophageal cancer | |
| Target gene or protein | EGFR, GOLM1,, FAS, ERα, PTEN, p21, Bax, p-PDK1, AKT, Cyclin D1, Bcl-2 | |
| Gene or Protein evidence | EGCG also inhibits activation of the EGFR in carcinoma cells, down-regulation of ER-α36 expression was in accordance with down-regulation of EGFR, which further verified a loop between ER-α36 and EGFR, GEN and EGCG reduced BRCA1 CpG methylation and cell proliferation associated with increased p53, The expression of FAS was also suppressed by the tea polyphenol (-)-epigallocatechin 3-gallate (EGCG) at both protein and mRNA levels that may lead to the inhibition of cell lipogenesis and proliferation. In all, EGCG is the first identified GOLM1 downregulation natural product. Western blot analysis revealed EGCG induced a concentration-dependent decrease in ERα protein levels, with a 56% reduction occurring with 60 µM EGCG when compared to controls. EGCG NPs modulate the expressions of several key regulatory proteins in PI3K-Akt pathway such as up-regulation of PTEN, p21 and Bax, and down-regulation of p-PDK1, p-AKT, CyclinD1 and Bcl-2 (MCF-7) | |
| Target pathways | HGF/HGFR/AKT/GSK-3β/β-catenin/c-Myc signaling pathway NF-κB pathway Arg-1/iNOS/Nox2/NF-κB/STAT3 signaling pathway EGF receptor/PI3K/Akt/Sp-1 signal transduction pathway | |
| IC50 | 7.5 µM against MCF- 7 | |
| Potency | NA | |
| Cell line/ mice model | MDA-MB-231, 4T1, , MCF-7, MCF-7tam,Hs578T, T47D, WI38VA, Caco-2, Hs578T, SUM-149, SUM-190, BT-20, BT-549, MDA-MB-435, HFF | |
| Additional information | Inhibits the CSF-1 and CCL-2 expression, up-regulates miR-16 (4T1 cells and exosomes) increases the proportions of CD4+ and CD8+ T cells in spleen and tumor sites (in 4T1 tumor bearing mice - IN VIVO) EGCG derivatives significantly block FASN activity, G28, M1, and M2 also diminish FASN protein expression levels | |
| PubChem ID | 65064 | |
| Additional PMIDs | 34536514 27187321 24044575 24749396 10518005 9719459 18978700 12421874 12925309 26341291 27231728 29742465 30917581 32784973 33807147 15965275 22827973 26206423 28911558 27806972 29504313 18025290 32012744 11673900 23880231 29040973 28930270 23664836 28346686 33587351 12925310 33957265 32143309 19017364 28579831 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:686606-1 | |
| Safety | NA |