| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1074 | |
| Phytochemical name or plant extracts | Epicatechin gallate | |
| PMID | 31404596 | |
| Literature evidence | Biocatalytically oligomerized epicatechin with potent and specific anti-proliferative activity for human breast cancer cells. | |
| IUPAC name | [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Garcinia mangostana | |
| Geographical availability | Borneo, Malaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer | |
| Target gene or protein | HIF-1, GLUT-1, VEGF, CDKN1A | |
| Gene or Protein evidence | (-)-epicatechin-3-gallate (ECG, 1), one of the major green tea catechins, strongly activates HIF-1 in T47D human breast carcinoma cells. , Compound 1 also increases the expression of HIF-1 target genes including GLUT-1, VEGF, and CDKN1A. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | T47D, MCF-7 | |
| Additional information | Epicatechin gallate (EGCG) significantly sensitizes MCF-7/TAM cells to tamoxifen and dramatically reduced Nrf2 expression at both the messenger RNA and protein, leading to a reduction of Nrf2-downstream genes. | |
| PubChem ID | 107905 | |
| Additional PMIDs | 26855680 29504313 30574049 32143309 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:428073-1 | |
| Safety | NA |