| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1332 | |
| Phytochemical name or plant extracts | Entelon | |
| PMID | 34203721 | |
| Literature evidence | Therefore, we propose the possibility of ETL as an effective adjuvant for treating TNBC. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Vitis vinifera Seed Extract | |
| Source of phytochemicals or plant Extracts | Vitis vinifera | |
| Geographical availability | Albania, Austria, Bulgaria, Corse, Cyprus, Czechoslovakia, France, Germany, Greece, Hungary, Iran, Iraq, Italy, Kirgizstan, Krym, Lebanon-Syria, North Caucasus, Palestine, Romania, Sardegna, Sicilia, Switzerland, Tadzhikistan, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, Yugoslavia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | IL1A | |
| Gene or Protein evidence | Suppressing the lung metastasis of TNBC cells through downregulation of IL1A. | |
| Target pathways | MEK/ERK and PI3K/AKT signaling pathway | |
| IC50 | NA | |
| Potency | Therefore, we demonstrate that the transcriptional activity of IL1A in TNBC cells is suppressed by a MEK/ERK- and PI3K/AKT-dependent pathway. Blockage of the MEK/ERK and PI3K/AKT pathway by ETL affected the downregulation of IL1A expression. | |
| Cell line/ mice model | 4T1, MDA-MB-231, Hs578T, MDA-MB-468 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30478388-2 | |
| Safety | NA |