| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-747 | |
| Phytochemical name or plant extracts | Ent-Kaur-16- en-19-oic acid | |
| PMID | 8882434 | |
| Literature evidence | Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). | |
| IUPAC name | (1S,4S,5R,9S,10R,13S)-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Diterpenoid | |
| Source of phytochemicals or plant Extracts | Annona senegalensis | |
| Geographical availability | Benin, Botswana, Burkina, Burundi, Cabinda, Cameroon, Cape Verde, Central African Repu, Chad, Comoros, Congo, Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Ivory Coast, Kenya, KwaZulu-Natal, Liberia, Madagascar, Malawi, Mali, Mozambique, Niger, Nigeria, Northern Provinces, Rwanda, Senegal, Sierra Leone, Sudan, Swaziland, Tanzania, Togo, Uganda, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Stem | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL). Compound 2 is Ent-Kaur-16- en-19-oic acid | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 microgram/mL). Compound 2 is Ent-Kaur-16- en-19-oic acid | |
| PubChem ID | 3034087 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:72309-1 | |
| Safety | NA |