| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-280 | |
| Phytochemical name or plant extracts | Emblica officinalis extract | |
| PMID | 14719119 | |
| Literature evidence | In this study we determined the activity of extracts from Bangladeshi medicinal plants (Emblica officinalis, Aegle marmelos, Vernonia anthelmintica, Oroxylum indicum, Argemone mexicana) on human breast tumor cell lines. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Emblica officinalis | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, East Himalaya, Hainan, India, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Pakistan, Sri Lanka, Sumatera, Taiwan, Thailand, Vietnam, West Himalaya | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | ERα mRNA | |
| Gene or Protein evidence | The data obtained demonstrated that only extracts from E. officinalis induce an increase of ERalpha mRNA in MCF7 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Extracts from E. officinalis and O. indicum displayed anti-proliferative activity on MCF7 and MDA-MB-231 breast cancer cell lines | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | E. officinalis specifically increased the expression levels of Fas, a critical member of the apoptotic pathway. | |
| PubChem ID | NA | |
| Additional PMIDs | 16119004 19723088 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:345266-1 | |
| Safety | NA |