| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-144 | |
| Phytochemical name or plant extracts | Elephantopus scaber extract | |
| PMID | 25829763 | |
| Literature evidence | Further, the ability of ES to inhibit multi drug resistant (MDR) transporters (ABC-B1 and ABC-G2) was determined by Rhodamine (Rho) and Mitoxantrone (MXR) efflux assays. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethanolic extract of ES (ES-ET) and its fractions, such as ES Petroleum ether fraction (ES-PET), ES Dichloromethane fraction (ES DCM), n Butyl alcohol fraction (ES-BT), and ES-Rest (ES-R) | |
| Source of phytochemicals or plant Extracts | Elephantopus scaber | |
| Geographical availability | Andaman Is., Angola, Assam, Bangladesh, Cambodia, Cameroon, China South-Central, China Southeast, Comoros, East Himalaya, Hainan, India, Jawa, Laos, Madagascar, Malaya, Mozambique, Myanmar, Nansei-shoto, Nepal, Nicobar Is., Sri Lanka, Taiwan, Tanzania, Thailand, Vietnam, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer, Lung cancer, Colon cancer | |
| Target gene or protein | ABCB1, ABCG2 | |
| Gene or Protein evidence | ES DCM caused enhanced sub G0 content and micronuclei formation indicating the induction of apoptosis and drug induced genotoxicity in cancer cells, respectively. Interestingly, ES DCM inhibited MDR transporters (ABC B1 and ABC G2) in cancer cells. | |
| Target pathways | NA | |
| IC50 | 18.33 ± 1.18 μg/mL against MCF-7 | |
| Potency | The enriched fraction of ES (ES DCM) possessed dose-dependent potent cytotoxicity in human epithelial cancer cells. Further, treatment of cancer cells (HeLa, A549, MCF-7, and Caco-2) with ES DCM showed hall mark properties of apoptosis | |
| Cell line/ mice model | HeLa, A549, MCF-7, Caco-2 | |
| Additional information | The enriched fraction of ES imparted cytotoxic effects, triggered apoptosis, induced genotoxicity, and inhibited MDR transporters in human epithelial cancer cells. Thus, ES appears to be potential anticancer agent. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:202958-1 | |
| Safety | NA |