| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1170 | |
| Phytochemical name or plant extracts | Eleostearic acid (alpha-ESA) | |
| PMID | 19789297 | |
| Literature evidence | We found that alpha-ESA inhibited proliferation of both MDA-wt and MDA-ERalpha7 cells, whereas conjugated linoleic acid had comparatively weak antiproliferative activity at 20 to 80 micromol/L concentrations. | |
| IUPAC name | octadeca-9,11,13-trienoic acid | |
| Phytochemicals’ class or type of plant extracts | Conjugated linolenic acid | |
| Source of phytochemicals or plant Extracts | Momordica charantia | |
| Geographical availability | Angola, Assam, Bangladesh, Benin, Borneo, Burkina, Burundi, Cameroon, Cape Verde, Central African Repu, Chad, Christmas I., Congo, East Himalaya, Ethiopia, Fiji, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., India, Ivory Coast, Jawa, Kenya, KwaZulu-Natal, Laos, Lesser Sunda Is., Liberia, Malawi, Malaya, Mali, Maluku, Mozambique, Namibia, Nepal, New Guinea, Niger, Nigeria, Northern Provinces, Northern Territory, Pakistan, Philippines, Queensland, Rwanda, Senegal, Sierra Leone, Society Is., Solomon Is., Sri Lanka, Sudan, Sulawesi, Sumatera, Tanzania, Thailand, Togo, Tonga, Uganda, Vanuatu, Vietnam, West Himalaya, Western Australia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer | |
| Target gene or protein | HER2/HER3, PTEN | |
| Gene or Protein evidence | Western blot analysis revealed that α-ESA treatment not only reduced HER2/HER3 protein expression, but also increased the level of phosphorylated phosphatase and tensin homolog protein (PTEN), which led to decreased levels of phosphorylated | |
| Target pathways | Akt/GSK-3β survival pathway , Akt/BAD/Bcl-2 apoptotic pathway | |
| IC50 | NA | |
| Potency | Alpha-ESA can block breast cancer cell proliferation and induce apoptosis through a mechanism that may be oxidation dependent. | |
| Cell line/ mice model | MDA-MB-231, SKBR-3, T47D | |
| Additional information | Therefore, α-ESA may be considered a beneficial dietary factor for the prevention and treatment of invasive breast cancer in cells overexpressing HER2. | |
| PubChem ID | 93077 | |
| Additional PMIDs | 24425042 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:293413-1 | |
| Safety | NA |