Phytochemical Name : Effususin B

Properties Information
PhytoCAT-ID PhytoCAT-1128
Phytochemical name or plant extracts Effususin B
PMID 26072042
Literature evidence Effususin B exhibited moderate to strong cytotoxic activities against the tested cancer cell lines and moderate anti-inflammatory activity.
IUPAC name NA
Phytochemicals’ class or type of plant extracts Phenanthrenoid dimer
Source of phytochemicals or plant Extracts Juncus effusus
Geographical availability Afghanistan, Alabama, Alaska, Albania, Algeria, Altay, Arizona, Arkansas, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bolivia, British Columbia, Bulgaria, Burundi, California, Cambodia, Canary Is., Central European Rus, China North-Central, China South-Central, China Southeast, Colombia, Connecticut, Corse, Costa Rica, Cyprus, Czechoslovakia, Delaware, Denmark, District of Columbia, East Aegean Is., East European Russia, East Himalaya, Ecuador, El Salvador, Finland, Florida, France, Free State, Føroyar, Georgia, Germany, Great Britain, Greece, Guatemala, Haiti, Honduras, Hungary, Iceland, Idaho, Illinois, India, Indiana, Iowa, Iran, Iraq, Ireland, Italy, Kansas, Kentucky, Kenya, Krasnoyarsk, Kriti, Krym, Leeward Is., Louisiana, Madagascar, Madeira, Maine, Manchuria, Manitoba, Maryland, Massachusetts, Mauritius, Mexican Pacific Is., Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Michigan, Minnesota, Mississippi, Missouri, Montana, Morocco, Nebraska, Netherlands, New Brunswick, New Hampshire, New Jersey, New York, Newfoundland, North Carolina, North Caucasus, North European Russi, Northern Provinces, Northwest European R, Norway, Nova Scotia, Ohio, Oklahoma, Ontario, Oregon, Palestine, Pennsylvania, Peru, Poland, Portugal, Prince Edward I., Québec, Rhode I., Romania, Rwanda, Sardegna, Sicilia, South Carolina, South European Russi, Spain, Svalbard, Sweden, Switzerland, Taiwan, Tanzania, Tennessee, Texas, Tibet, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Uganda, Ukraine, Venezuela, Vermont, Virginia, Washington, West Himalaya, West Siberia, West Virginia, Wisconsin, Yugoslavia, Zaïre, Zimbabwe
Plant parts Medullae
Other cancers Breast cancer, Cervical cancer, Liver cancer
Target gene or protein NA
Gene or Protein evidence NA
Target pathways NA
IC50 12.49 ± 1.33 μM against MCF-7
Potency Effususin B exhibited moderate to strong cytotoxic activities against the tested cancer cell lines and moderate anti-inflammatory activity.
Cell line/ mice model SHSY-5Y, SMMC-7721, HepG2, Hela, and MCF-7
Additional information  The medullae of J. effusus is used in traditional medicine as antipyretic and antiphlogistic agents and also as sedative agent in China, Japan and other district of the Far East
PubChem ID NA
Additional PMIDs NA
Additional sources of information https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:442917-1
Safety NA