| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-49 | |
| Phytochemical name or plant extracts | Eclipta alba extract (CFEA) | |
| PMID | 26672742 | |
| Literature evidence | Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Chloroform fraction, Alcoholic extract | |
| Source of phytochemicals or plant Extracts | Eclipta alba | |
| Geographical availability | Alabama, Argentina Northeast, Argentina Northwest, Arizona, Arkansas, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Brazil South, Brazil Southeast, Brazil West-Central, California, Chile Central, Chile North, Chile South, Colombia, Connecticut, Costa Rica, Cuba, Delaware, District of Columbia, Dominican Republic, Ecuador, El Salvador, Florida, French Guiana, Georgia, Guatemala, Guyana, Haiti, Honduras, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Michigan, Minnesota, Mississippi, Missouri, Nebraska, New Jersey, New Mexico, New York, Nicaragua, North Carolina, Ohio, Oklahoma, Ontario, Panamá, Paraguay, Pennsylvania, Peru, Puerto Rico, Rhode I., South Carolina, South Dakota, Suriname, Tennessee, Texas, Trinidad-Tobago, Uruguay, Venezuela, Vermont, Virginia, West Virginia, Wisconsin | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Hsp60, XIAP | |
| Gene or Protein evidence | Our unbiased mechanistic hunt revealed that CFEA specifically activates the intrinsic apoptotic pathway by disrupting the mitochondrial membrane potential, upregulating Hsp60 and downregulating the expression of anti-apoptotic protein XIAP. | |
| Target pathways | Intrinsic apoptotic pathway | |
| IC50 | NA | |
| Potency | Together, our studies offer novel mechanistic insight into the CFEA mediated inhibition of breast cancer and may potentially open up new avenues for further translational research. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, mouse breast cancer 4T1, MCF 10A | |
| Additional information | Moreover, oral administration of CFEA not only offers potential anti-breast cancer effects in-vivo but also mitigates tumor induced hepato-renal toxicity. By utilizing Hsp60 specific siRNA, we identified a novel pro-apoptotic role of Hsp60 and uncovered that following CFEA treatment, upregulated Hsp60 is localized in the endoplasmic reticulum (ER). To our knowledge, this is the first evidence of ER specific localization of Hsp60 during cancer cell apoptosis. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer. | |
| PubChem ID | NA | |
| Additional PMIDs | 28250894 33225921 33807771 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1186403-2 | |
| Safety | CFEA has shown minimal cytotoxicity against MCF 10A but on the same dose, it poses marked cytotoxic effects to MCF-7 cells. |