| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1362 | |
| Phytochemical name or plant extracts | Echinophora platyloba extract | |
| PMID | 29755561 | |
| Literature evidence | This extract could induce apoptosis and promote cell-cycle arrest at S-phase in MDA-MB-231 cells after 24 h of incubation, as compared to the control group (p < 0.001) and could significantly up-regulate the expression of bax and p27 genes at the level of 2.8 and 2.2 folds, respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Echinophora Platyloba | |
| Geographical availability | Iran | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, p27, Bax | |
| Gene or Protein evidence | The results indicate that the present plant extract could cause a significant amount of apoptosis in MDA- MB 231 cells mainly via altering the bax and bcl-2 expression. Gene expression analysis in this study showed that the crude extract –could induce S-phase cell cycle arrest, which was thought to be mediated through the increased expression of CDKI mRNAs (p27 but not p21). | |
| Target pathways | NA | |
| IC50 | 534.6 ± 7.2 µg/mL against MDA-MB-231 for 24h | |
| Potency | Our data showed 534.6 ± 7.2 µg/mL of extract following 24 h of incubation was the most cytotoxic dose against MDA-MB-231 cells in comparison with other doses. This extract could induce apoptosis and promote cell-cycle arrest at S-phase in MDA-MB-231 cells after 24 h of incubation | |
| Cell line/ mice model | MDA-MB-231, MCF-10a | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:841510-1 | |
| Safety | Nonetheless, the IC50 of crude methanolic extract was higher on the positive control cell line (IC50 > 900 ?g/mL), MCF-10A as compared to the MDA-MB-231 cells. |