| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-507 | |
| Phytochemical name or plant extracts | Ebenfuran I | |
| PMID | 15579325 | |
| Literature evidence | We examined their ability, (1) to induce the insulin growth factor binding protein-3 (IGFBP-3) in MCF-7 breast cancer cells, (2) to stimulate differentiation and mineralization of osteoblastic cell culture by histochemical staining for alkaline phosphatase, Alizarin Red-S staining and calcium levels in the supernatants and (3) to inhibit cell proliferation of cervical adenocarcinoma (Hela) cells by use of the MTT assay. | |
| IUPAC name | 4-(5-hydroxy-6-methoxy-1-benzofuran-2-yl)benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Benzofuran | |
| Source of phytochemicals or plant Extracts | Onobrychis ebenoides | |
| Geographical availability | Greece | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Cervical cancer, Osteoporosis | |
| Target gene or protein | IGFBP-3 | |
| Gene or Protein evidence | (1) to induce the insulin growth factor binding protein-3 (IGFBP-3) in MCF-7 breast cancer cells | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | In conclusion, our study is the first to demonstrate that plant derived arylobenzofurans show a SERM profile and may be considered for the prevention and treatment of diseases such as breast cancer, cervical cancer and osteoporosis. | |
| Cell line/ mice model | MCF-7, MC3T3-E1, HeLa | |
| Additional information | NA | |
| PubChem ID | 10265236 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:509922-1 | |
| Safety | NA |