| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1356 | |
| Phytochemical name or plant extracts | Diospyros lycioides extract | |
| PMID | 26457109 | |
| Literature evidence | The extract in this study was shown to induce apoptosis at an early stage which makes it an ideal source that can be explored for compounds that may be used in the treatment and management of cancer. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Acetone extract | |
| Source of phytochemicals or plant Extracts | Diospyros lycioides | |
| Geographical availability | Angola, Botswana, Cape Provinces, Caprivi Strip, Free State, KwaZulu-Natal, Lesotho, Malawi, Mozambique, Namibia, Northern Provinces, Swaziland, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | p53, Bcl-2, enolase, pyruvate kinase, glyceraldehyde-3-phosphate | |
| Gene or Protein evidence | The extract was also shown to upregulate the expression of p53 gene with concomitant downregulation of the Bcl-2 antiapoptotic gene while differentially expressed proteins were identified as enolase, pyruvate kinase, and glyceraldehyde-3-phosphate. | |
| Target pathways | the death receptor (extrinsic) and the mitochondrial (intrinsic) pathways. | |
| IC50 | 65 µg/mL against MCF-7 | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | the acetone leaf extract of DL to possess antioxidant activity both as a reducing agent and as a free radical scavenger. Our data also revealed that the DL extract exerts its antiproliferative effects by inducing apoptosis in MCF-7 breast cancer cells in a p53-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:322637-1 | |
| Safety | NA |