| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1095 | |
| Phytochemical name or plant extracts | Diospyros lotus extract | |
| PMID | 19731038 | |
| Literature evidence | Among identified hydrolysable tannins, ellagic acid evidenced strong antiproliferative activity against both C32 and A375 cells with IC50 values of 0.8 and 4.1 microg/ml, respectively. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract | |
| Source of phytochemicals or plant Extracts | Diospyros lotus | |
| Geographical availability | Afghanistan, China North-Central, China South-Central, China Southeast, Iran, Korea, Manchuria, Nepal, North Caucasus, Pakistan, Tadzhikistan, Tibet, Transcaucasus, Turkey, West Himalaya | |
| Plant parts | Fruits | |
| Other cancers | Breast cancer, Lung cancer, Colorectal cancer, Prostate cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | >100 μg/ml against MCF-7 | |
| Potency | Overall, the results of this study suggest that D. lotus displays a good antioxidant activity and has antiproliferative effects. | |
| Cell line/ mice model | MCF-7, COR-L23, CaCo-2, C32, ACHN, A375, A549, Huh-7D12 and LNCaP | |
| Additional information | In conclusion, crude extract and 7-methyljuglone of D. lotus roots possessed both peripheral and central antinociceptive potential and thus could be a useful new therapeutic agent. | |
| PubChem ID | NA | |
| Additional PMIDs | 25604725 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:322629-1 | |
| Safety | NA |