| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-809 | |
| Phytochemical name or plant extracts | Diosmetin | |
| PMID | 19424633 | |
| Literature evidence | We have examined the ability of the natural flavone diosmetin to inhibit proliferation of breast adenocarcinoma MDA-MB 468 and normal breast MCF-10A cells and found that this compound is selective for the cancer cells with slight toxicity in the normal breast cells. | |
| IUPAC name | 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Dictamnus dasycarpus | |
| Geographical availability | Amur, China North-Central, China South-Central, China Southeast, Chita, Inner Mongolia, Khabarovsk, Korea, Manchuria, Mongolia, Primorye, Xinjiang | |
| Plant parts | Bark | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, Cyclin D1, p53, Bax, Caspase 3, Caspase 9, Caspase 3 | |
| Gene or Protein evidence | Moreover, diosmetin treatment significantly downregulated the expression levels of Bcl-2 and Cyclin D1, and upregulated that of p53, Bax, caspase 3, cleaved caspase 9, and cleaved caspase 3. | |
| Target pathways | Mitochondria-Mediated Intrinsic Apoptotic Pathway | |
| IC50 | 4.5 μM against MDA-MB-468 | |
| Potency | EC50=2.9 microM in MCF-7 | |
| Cell line/ mice model | MDA-MB-468, MCF-7, MDA-MB-231 | |
| Additional information | Our results extend the understanding of the anti-tumor mechanism of diosmetin and suggest that it may be of use as an active natural agent for the prevention or treatment of human breast cancer. | |
| PubChem ID | 5281612 | |
| Additional PMIDs | 31284642 18596662 30717533 17294687 25560707 10923837 33464702 18976853 19101886 18835421 19424633 31228347 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:772363-1 | |
| Safety | NA |