| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-249 | |
| Phytochemical name or plant extracts | Dioscorealide B | |
| PMID | 21299121 | |
| Literature evidence | Taken together, the results of this study provide evidence that dioscorealide B possesses an antitumor property against human breast cancer cells and thus provide the molecular basis for the further development of dioscorealide B as a novel chemotherapeutic agent for breast cancer treatment. | |
| IUPAC name | (6S)-6-hydroxy-5,10-dimethoxy-3,7-dioxatetracyclo[6.6.2.04,15.012,16]hexadeca-1(15),4,8(16),9,11,13-hexaen-2-one | |
| Phytochemicals’ class or type of plant extracts | Macrocyclic lactone | |
| Source of phytochemicals or plant Extracts | Dioscorea membranacea | |
| Geographical availability | Cambodia, Laos, Malaya, Myanmar, Thailand, Vietnam | |
| Plant parts | Rhizome | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bak, Bcl-2, Caspase 8, Caspase 9, Caspase 7 | |
| Gene or Protein evidence | After treatment with 3 microM dioscorealide B, acceleration of the level of proapoptotic proteins Bax and Bak were observed at 6 hours and 12 hours, respectively, while the decrease in the expression of antiapoptotic protein Bcl-2 was observed 3 hours after the treatment. These effects of dioscorealide B might result in the activation of caspase-8, -9 and -7, which lead to apoptosis in MCF-7 cells. | |
| Target pathways | p53 and the intrinsic apoptotic pathway. | |
| IC50 | 2.76 µM against MCF-7 9.93 µM against MDA-MB-468 | |
| Potency | Dioscorealide B-induced apoptosis was associated with modulation of the multidomain Bcl-2 family members Bax, Bak and Bcl-2. | |
| Cell line/ mice model | NA | |
| Additional information | NA | |
| PubChem ID | 11044777 | |
| Additional PMIDs | 21294426 21299121 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:318257-1 | |
| Safety | NA |