| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1093 | |
| Phytochemical name or plant extracts | Dioscorea bulbifera extract | |
| PMID | 33505506 | |
| Literature evidence | Antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assays, while the cytotoxicity of D. bulbifera on MDA-MB-231 and MCF-7 breast cancer cell lines was tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract | |
| Source of phytochemicals or plant Extracts | Dioscorea bulbifera | |
| Geographical availability | Andaman Is., Angola, Assam, Bangladesh, Benin, Borneo, Burkina, Burundi, Cambodia, Cameroon, Caprivi Strip, Caroline Is., Central African Repu, Chad, China North-Central, China South-Central, China Southeast, Christmas I., Congo, East Himalaya, Eritrea, Ethiopia, Gabon, Ghana, Guinea, Guinea-Bissau, Gulf of Guinea Is., Hainan, India, Ivory Coast, Japan, Jawa, Kenya, Korea, Laccadive Is., Laos, Lesser Sunda Is., Liberia, Madagascar, Malawi, Malaya, Mali, Mozambique, Myanmar, Nansei-shoto, Nepal, New Guinea, Nigeria, Northern Territory, Pakistan, Philippines, Queensland, Rwanda, Senegal, Sierra Leone, Sri Lanka, Sudan, Sulawesi, Sumatera, Taiwan, Tanzania, Thailand, Tibet, Togo, Uganda, Vanuatu, Vietnam, West Himalaya, Western Australia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Colorectal cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | At 24h, 48h, 72h: 8.96 μg/mL, 6.88 μg/mL, 3.27 μg/mL against MCF-7 respectively 14.29 μg/mL, 11.86 μg/mL, 7.23 μg/mL against MDA-MB-231 respectively | |
| Potency | Hence, these findings concluded that D. bulbifera extract has promising anticancer and natural antioxidant agents. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, HCT116 | |
| Additional information | Dioscorea bulbifera induced apoptosis through inhibition of ERK 1/2 and activation of JNK signaling pathways in HCT116 human colorectal carcinoma cells | |
| PubChem ID | NA | |
| Additional PMIDs | 29860114 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:323908-2 | |
| Safety | NA |