| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1821 | |
| Phytochemical name or plant extracts | Dillenia suffruticosa extract(EADs) | |
| PMID | 24524627 | |
| Literature evidence | Therefore, EADs has the potential to act as an effective intervention against breast cancer cells. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Dillenia suffruticosa | |
| Geographical availability | Borneo, Malaya, Philippines, Sumatera | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | SOD1, SOD2, p53, p21. | |
| Gene or Protein evidence | EADs is postulated to induce cell cycle arrest that is p53- and p21-dependent based on the upregulated expression of p53 and p21, EADs-induced apoptosis was accompanied by upregulation of the expression of SOD1, SOD2, NF-κB, p53, p38 MAPK, and catalase, but downregulation of Akt1. | |
| Target pathways | EADs generated oxidative stress, induced cell cycle arrest and apoptosis in MCF-7 cells by regulating numerous genes and proteins that are involved in the apoptotic signal transduction pathway. | |
| IC50 | At 24h, 48h, 72h: 76 ± 2.3 μg/mL, 58 ± 0.7 μg/mL and 39 ± 3.6 μg/mL against MCF-7, respectively. | |
| Potency | It shows the potential of EADs to be developed into an anticancer agent. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | EADs generated oxidative stress, induced cell cycle arrest and apoptosis in MCF-7 cells by regulating numerous genes and proteins that are involved in the apoptotic signal transduction pathway.. Betulinic acid, which is one of the major compounds, is responsible for the cytotoxicity of the DCM-DS. Therefore, BA can be used as a marker for standardisation of herbal product from D. suffruticosa.. Betulinic acid, which is one of the major compounds, is responsible for the cytotoxicity of the DCM-DS. Therefore, BA can be used as a marker for standardisation of herbal product from D. suffruticosa. | |
| PubChem ID | NA | |
| Additional PMIDs | 26047480 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316765-1 | |
| Safety | NA |