| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1962 | |
| Phytochemical name or plant extracts | Dihydrocapsaicin | |
| PMID | 33833997 | |
| Literature evidence | Taken together, DHC may serve as a candidate natural compound for human melanoma treatment through β-catenin pathway. | |
| IUPAC name | N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnonanamide | |
| Phytochemicals’ class or type of plant extracts | Capsaicinoid | |
| Source of phytochemicals or plant Extracts | Capsicum annuum. Zingiber officinale Roscoe | |
| Geographical availability | Capsicum annuum L. - Arizona, Bahamas, Belize, Bolivia, Brazil North, Brazil Northeast, Cayman Is., Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Florida, Guatemala, Guyana, Haiti, Honduras, Jamaica, Leeward Is., Louisiana, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Peru, Puerto Rico, Southwest Caribbean, Suriname, Texas, Trinidad-Tobago, Turks-Caicos Is., Venezuela, Windward Is. Zingiber officinale Roscoe - Assam, China South-Central, East Himalaya, India | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Colorectal cancer, Glioma | |
| Target gene or protein | Caspase family CASP9, CASP3, Bax | |
| Gene or Protein evidence | The results showed that dihydrocapsaicin could inhibit the proliferation and migration of triple negative breast cancer MDA-MB-231 cells, and up-regulate the mRNA expression of Caspase family CASP9 and the protein expression of CASP3 and BAX. | |
| Target pathways | DHC may participate in the regulation of PI3K/AKT signaling pathway by inhibiting the expression of PI3K and AKT proteins or promoting the expression of PTEN protein. | |
| IC50 | 125.4 µM against MDA-MB-231 | |
| Potency | The results showed that dihydrocapsaicin could inhibit the proliferation and migration of triple negative breast cancer MDA-MB-231 cells, and up-regulate the mRNA expression of Caspase family CASP9 and the protein expression of CASP3 and BAX. | |
| Cell line/ mice model | MDA-MB-231 | |
| Additional information | The results of molecular docking showed that the lowest binding potential energy between dihydrocapsaicin (DHC) and EGFR protein was -7.70 kcal·mol-1, followed by that between 6-gingerol and EGFR protein was -7.30 kcal·mol-1 and that between DHC and CASP3 protein was -7.20 kcal·mol-1. | |
| PubChem ID | 107982 | |
| Additional PMIDs | 37113393 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:316944-2 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:798372-1 | |
| Safety | NA |