| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1940 | |
| Phytochemical name or plant extracts | Dicranopteris linearis extract (MEDL) | |
| PMID | 30301390 | |
| Literature evidence | MEDL could induce S phase cell cycle arrest after 72 h of incubation. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Methanolic extract (MEDL), Petroleum ether (PEEDL) extract | |
| Source of phytochemicals or plant Extracts | Dicranopteris linearis | |
| Geographical availability | Andaman Is., Angola, Assam, Bangladesh, Bismarck Archipelago, Borneo, Burundi, Cambodia, Cameroon, Cape Provinces, Caroline Is., China South-Central, China Southeast, Comoros, Cook Is., East Himalaya, Equatorial Guinea, Ethiopia, Fiji, Gabon, Ghana, Guinea, Gulf of Guinea Is., Hainan, Hawaii, India, Ivory Coast, Japan, Jawa, Kenya, KwaZulu-Natal, Laos, Lesser Sunda Is., Liberia, Madagascar, Malawi, Malaya, Maluku, Marianas, Marquesas, Mauritius, Mozambique, Myanmar, Nansei-shoto, Nepal, New Caledonia, New Guinea, New South Wales, New Zealand North, Nicobar Is., Nigeria, Northern Provinces, Northern Territory, Philippines, Pitcairn Is., Queensland, Rwanda, Réunion, Samoa, Seychelles, Sierra Leone, Society Is., Solomon Is., Sri Lanka, Sulawesi, Sumatera, Swaziland, Taiwan, Tanzania, Thailand, Tonga, Tuamotu, Tubuai Is., Uganda, Vanuatu, Vietnam, Wallis-Futuna Is., Western Australia, Zambia, Zaïre, Zimbabwe | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer, Cervical cancer, Colon cancer, Liver cancer, Lung cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 22.4 ± 0.5 µg/mL against MDA-MB-231 97.2 ± 0.5 µg/mL against MCF-7 | |
| Potency | MEDL has potential as a potent cytotoxic agent against MDA-MB-231 adenocarcinoma. | |
| Cell line/ mice model | A549, HeLa, HepG2, HT-29, MCF-7, MDA-MB-231 | |
| Additional information | MEDL induces apoptosis in MDA-MB-231 cells in a time-dependent manner. In addition, MEDL has also been proven to play a role in cell cycle progression by inducing the S phase arrest in MDA-MB-231 cells in a time-dependent manner. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:17245530-1 | |
| Safety | NA |