| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-494 | |
| Phytochemical name or plant extracts | Dibenzoylmethane | |
| PMID | 25650742 | |
| Literature evidence | They inhibit cellular proliferation and induce apoptosis in a variety of types of cancer cell, however, the antimetastatic effects of DB, HDB and HMDB on human breast carcinoma cells remain to be elucidated. | |
| IUPAC name | 1,3-diphenylpropane-1,3-dione | |
| Phytochemicals’ class or type of plant extracts | Beta-diketone | |
| Source of phytochemicals or plant Extracts | Glycyrrhiza inflata | |
| Geographical availability | China North-Central, Inner Mongolia, Mongolia, Xinjiang | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Lung cancer | |
| Target gene or protein | MMP9 | |
| Gene or Protein evidence | In addition, PMA‑mediated MCF‑7 cell invasion was inhibited by DB, HDB and HMDB by inhibiting the expression of matrix metalloproteinase (MMP)‑9. | |
| Target pathways | PI3K/PKCδ‑mediated MMP‑9 pathway. | |
| IC50 | NA | |
| Potency | DB, HDB and HMDB prevented the activation of PKCδ and PI3K by inhibiting their phosphorylation. The present study was the first, to the best of our knowledge, to demonstrate the antimetastatic potential of DB, HDB and HDMB, which decreased cancer cell invasion through the PI3K/PKCδ‑mediated MMP‑9 pathway. | |
| Cell line/ mice model | MCF‑7 | |
| Additional information | The results revealed that DB, HDB and HMDB inhibited cell migration and invasion. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:496952-1 | |
| Safety | NA |