| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1057 | |
| Phytochemical name or plant extracts | Diallyl trisulfide | |
| PMID | 22981381 | |
| Literature evidence | MCF-7 cells treated with DATS also exhibited increased DNA binding activity of AP-1, which was blocked by NAC and the JNK inhibitor. | |
| IUPAC name | 3-(prop-2-enyltrisulfanyl)prop-1-ene | |
| Phytochemicals’ class or type of plant extracts | Organosulfur | |
| Source of phytochemicals or plant Extracts | Allium sativum | |
| Geographical availability | Iran, Kazakhstan, Kirgizstan, Tadzhikistan, Turkmenistan, Uzbekistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bcl-2, PARP, JNK | |
| Gene or Protein evidence | DATS induced phosphorylation of the antiapoptotic Bcl-2 and proteolytic cleavage of poly(ADP-ribose)polymerase (PARP) in MCF-7 cells. DATS treatment activated c-Jun N-terminal kinase (JNK). | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Oral administration of 5μmol/kg DATS to female Balb/c mice inhibited the growth of human MCF-7 cell tumor xenografts. These results suggest that DATS-induced apoptosis is mediated through ROS generation and subsequent activation of JNK and AP-1. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 16315 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528796-1 | |
| Safety | NA |