| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-537 | |
| Phytochemical name or plant extracts | Diallyl disulphide | |
| PMID | 23163853 | |
| Literature evidence | Histone deacetylation inhibitors (HDACi) are known to suppress cancer growth and induce apoptosis in cancer cells. | |
| IUPAC name | 3-(prop-2-enyldisulfanyl)prop-1-ene | |
| Phytochemicals’ class or type of plant extracts | Organosulfur | |
| Source of phytochemicals or plant Extracts | Allium vineale | |
| Geographical availability | Albania, Algeria, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Corse, Czechoslovakia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Krym, Lebanon-Syria, Morocco, Netherlands, Norway, Poland, Portugal, Romania, Sardegna, Sicilia, Spain, Sweden, Switzerland, Transcaucasus, Turkey, Turkey-in-Europe, Ukraine, Yugoslavia | |
| Plant parts | Bulb | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Bcl-w, Bcl-xL | |
| Gene or Protein evidence | Further studies revealed that DADS modulates the cellular levels of Bax, Bcl-2, Bcl-xL, and Bcl-w in a dose-dependent manner, suggesting the involvement of Bcl-2 family proteins in DADS induced apoptosis. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The data thus indicate that the HDACi properties of DADS may be responsible for the induction of apoptosis in breast cancer cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Here it is shown that DADS has HDACi properties in MCF-7 cells as it lowers the removal of an acetyl group from an acetylated substrate and induces histone-4 (H4) hyper-acetylation. | |
| PubChem ID | 16590 | |
| Additional PMIDs | 15827557 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:529111-1 | |
| Safety | NA |