| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1056 | |
| Phytochemical name or plant extracts | Diallyl disulfide | |
| PMID | 22981381 | |
| Literature evidence | MCF-7 cells treated with DATS also exhibited increased DNA binding activity of AP-1, which was blocked by NAC and the JNK inhibitor. | |
| IUPAC name | 3-(prop-2-enyldisulfanyl)prop-1-ene | |
| Phytochemicals’ class or type of plant extracts | Organosulfur | |
| Source of phytochemicals or plant Extracts | Allium sativum | |
| Geographical availability | Iran, Kazakhstan, Kirgizstan, Tadzhikistan, Turkmenistan, Uzbekistan | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Bax, Bcl-2, Bcl-xL, Bcl-w | |
| Gene or Protein evidence | Further studies revealed that DADS modulates the cellular levels of Bax, Bcl-2, Bcl-xL, and Bcl-w in a dose-dependent manner, suggesting the involvement of Bcl-2 family proteins in DADS induced apoptosis. | |
| Target pathways | DADS was shown to cause caspase-dependent apoptosis in human breast cancer cells MCF-7 through the Bax-triggered mitochondrial pathway | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 | |
| Additional information | Here it is shown that DADS has HDACi properties in MCF-7 cells as it lowers the removal of an acetyl group from an acetylated substrate and induces histone-4 (H4) hyper-acetylation. | |
| PubChem ID | 16590 | |
| Additional PMIDs | 23163853 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:528796-1 | |
| Safety | NA |