| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1815 | |
| Phytochemical name or plant extracts | Desoxyrhaponticin | |
| PMID | 24362821 | |
| Literature evidence | We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. | |
| IUPAC name | (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | |
| Phytochemicals’ class or type of plant extracts | Stilbene glycosides | |
| Source of phytochemicals or plant Extracts | Rheum tanguticum Maxim ex Balf | |
| Geographical availability | China North-Central, Qinghai, Tibet | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Fatty acid synthase (FAS) | |
| Gene or Protein evidence | We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 5316606 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:696803-1 | |
| Safety | NA |