| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-824 | |
| Phytochemical name or plant extracts | Descurainia sophia volatile oil | |
| PMID | 26487894 | |
| Literature evidence | Different extracts of aerial parts and seeds of this plant have been shown to inhibit the growth of different cancer cell lines in vitro. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Volatile oil | |
| Source of phytochemicals or plant Extracts | Descurainia sophia | |
| Geographical availability | Afghanistan, Albania, Algeria, Altay, Austria, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Buryatiya, Central European Rus, China North-Central, China South-Central, China Southeast, Chita, Corse, Czechoslovakia, Denmark, East European Russia, East Himalaya, Egypt, Finland, France, Germany, Greece, Hungary, Iceland, Inner Mongolia, Iran, Iraq, Irkutsk, Italy, Japan, Kazakhstan, Kirgizstan, Korea, Krasnoyarsk, Kriti, Krym, Kuwait, Lebanon-Syria, Manchuria, Mongolia, Morocco, Nepal, Netherlands, North Caucasus, North European Russi, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Qinghai, Romania, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Tibet, Transcaucasus, Turkey, Turkey-in-Europe, Turkmenistan, Tuva, Ukraine, Uzbekistan, West Himalaya, West Siberia, Xinjiang, Yakutskiya, Yugoslavia | |
| Plant parts | Seeds | |
| Other cancers | Breast cancer, Cervical cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | < 100 μg/ml against MCF-7 | |
| Potency | The results of cytotoxic evaluations showed that volatile constituents were more toxic on MCF-7 cells with IC50< 100 μg/ml than HeLa cells with IC50> 100 μg/ml. | |
| Cell line/ mice model | MCF-7, HeLa | |
| Additional information | Concomitant use of E1 and E2 (50 μg/ml) with doxurubicin (1 μM) significantly reduced the viability of MCF-7 cells compared to the negative control, doxorubicin alone, or each volatile fraction. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:78248-2 | |
| Safety | NA |