| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1064 | |
| Phytochemical name or plant extracts | Desacetyl nimbinene (DAN) | |
| PMID | 26637227 | |
| Literature evidence | Phytochemicals are potent source of anticancer drugs as wells as potential inducers of ROS. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | NA | |
| Source of phytochemicals or plant Extracts | Azadirachta indica | |
| Geographical availability | Assam, Bangladesh, Cambodia, Laos, Myanmar, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | JNK, p38, SOD1, SOD2 | |
| Gene or Protein evidence | Increased phosphorylation of c-Jun-N-terminal kinase (JNK) and reduced phosphorylation of p38 were also observed in response to DAN treatment.. Inhibition of ROS production by overexpressing antioxidant enzymes SOD1 and SOD2 reduced the DAN-induced cytotoxicity. | |
| Target pathways | This results show that DAN initially induces mitochondria mediated apoptosis followed by the death receptor pathway. | |
| IC50 | 35 μM against breast cancer cells | |
| Potency | Overall, our data suggest that DAN exerts its anticancer effect on breast cancer by induction of mitochondria-mediated apoptosis mediated by ROS accumulation. | |
| Cell line/ mice model | MCF-7, MDA-MB-231 | |
| Additional information | Additionally, DAN significantly inhibited migration and invasion of MDA-MB-231 breast cancer cells. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1213180-2 | |
| Safety | NA |