| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-437 | |
| Phytochemical name or plant extracts | Derrone | |
| PMID | 26983907 | |
| Literature evidence | This compound exhibited an ability to inhibit the phosphorylation of histone H3 at ser10 both in kinase assay and at the cellular level. | |
| IUPAC name | 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethylpyrano[2,3-h]chromen-4-one | |
| Phytochemicals’ class or type of plant extracts | Flavonoid | |
| Source of phytochemicals or plant Extracts | Erythrina orientalis | |
| Geographical availability | Aldabra, Andaman Is., Assam, Bangladesh, Bismarck Archipelago, Borneo, Cambodia, Caroline Is., China South-Central, China Southeast, Christmas I., Cocos (Keeling) Is., Comoros, Cook Is., East Himalaya, Fiji, Hainan, India, Jawa, Laccadive Is., Laos, Lesser Sunda Is., Madagascar, Malaya, Maldives, Maluku, Marianas, Marquesas, Marshall Is., Myanmar, Nansei-shoto, Nauru, New Caledonia, New Guinea, Nicobar Is., Niue, Northern Territory, Philippines, Queensland, Samoa, Seychelles, Society Is., Solomon Is., South China Sea, Sri Lanka, Sulawesi, Sumatera, Taiwan, Tanzania, Thailand, Tonga, Tuamotu, Tubuai Is., Vanuatu, Vietnam, West Himalaya | |
| Plant parts | Stem | |
| Other cancers | Breast cancer, Lung cancer, Cervical cancer | |
| Target gene or protein | Aurora kinases | |
| Gene or Protein evidence | However, our results provide the evidence that Derrone inhibited Aurora kinases in vitro from assay level to cellular level. | |
| Target pathways | NA | |
| IC50 | 13.6 ± 1.9 µM against MCF-7 | |
| Potency | This compound exhibited an ability to inhibit the phosphorylation of histone H3 at ser10 both in kinase assay and at the cellular level. The compound was more effective against Aurora kinase B, with a lower IC50 value as compared to Aurora A. | |
| Cell line/ mice model | MCF-7, HeLa, KPL4, H1299 | |
| Additional information | Additionally, Derrone inhibited the growth of tumor spheroids. Thus, this compound could be a potential anticancer drug. | |
| PubChem ID | 14704457 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:494523-1 | |
| Safety | NA |