| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-710 | |
| Phytochemical name or plant extracts | Deoxyrhapontigenin | |
| PMID | 27151591 | |
| Literature evidence | Although current chemotherapeutic agents are active at the beginning of therapy, the most common risk is the development of resistance during later stages in almost all cancer types including breast cancer. | |
| IUPAC name | 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol | |
| Phytochemicals’ class or type of plant extracts | Stilbenoid | |
| Source of phytochemicals or plant Extracts | Rheum undulatum | |
| Geographical availability | Buryatiya, China North-Central, China South-Central, Chita, Inner Mongolia, Irkutsk, Manchuria, Mongolia | |
| Plant parts | Root | |
| Other cancers | Breast cancer | |
| Target gene or protein | GRP78, IRE1α, eIF2α, CHOP, JNK, p38 | |
| Gene or Protein evidence | Mechanistic investigations revealed that DR treatment causes endoplasmic reticulum (ER) dilation and upregulated the expression of ER stress markers GRP78, IRE1α, eIF2α, CHOP, JNK, and p38. | |
| Target pathways | ER stress-mediated apoptosis pathway | |
| IC50 | NA | |
| Potency | In summary, the present study suggests that the induction of ER stress-mediated apoptosis by DR may account for its cytotoxic effects in human breast cancer cells. | |
| Cell line/ mice model | MCF-7, MCF-7/adr | |
| Additional information | Subsequently, we also identified that DR increases the levels of apoptotic fragment of PARP (89 kDa) in breast cancer cells. Blocking the expression of one of the components of the ER stress-mediated apoptosis pathway, CHOP using siRNA significantly decreased DR-induced apoptotic cleavage of PARP. | |
| PubChem ID | 6255462 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:696808-1 | |
| Safety | NA |