| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1735 | |
| Phytochemical name or plant extracts | Deoxyelephantopin | |
| PMID | 20105176 | |
| Literature evidence | Moreover, tumour necrosis factor alpha-induced matrix metalloproteinase-9 enzyme activity and expression and nuclear factor-kappa B activation were abolished by DET. | |
| IUPAC name | [(3S,4R,8R,9E,12R)-10-methyl-5-methylidene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.04,8]pentadeca-1(15),9-dien-3-yl] 2-methylprop-2-enoate | |
| Phytochemicals’ class or type of plant extracts | Sesquiterpene lactone | |
| Source of phytochemicals or plant Extracts | Elephantopus scaber | |
| Geographical availability | Andaman Is., Angola, Assam, Bangladesh, Cambodia, Cameroon, China South-Central, China Southeast, Comoros, East Himalaya, Hainan, India, Jawa, Laos, Madagascar, Malaya, Mozambique, Myanmar, Nansei-shoto, Nepal, Nicobar Is., Sri Lanka, Taiwan, Tanzania, Thailand, Vietnam, Zambia, Zaïre, Zimbabwe | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | p21(Waf1/Cip1), MMP9, NF-kB | |
| Gene or Protein evidence | c-Jun N-terminal kinase-mediated p21(Waf1/Cip1) expression and caspase activation cascades were up-regulated by DET, effects suppressed by N-acetyl-L-cysteine. Moreover, tumour necrosis factor alpha-induced matrix metalloproteinase-9 enzyme activity and expression and nuclear factor-kappa B activation were abolished by DET. Pretreatment with DET was more effective than paclitaxel, for profound suppression of orthotopic tumour growth (99% vs. 68% reduction in tumour size) and lung metastasis of TS/A cells (82% vs. 63% reduction in metastatic pulmonary foci) and prolonged median survival time (56 vs. 37 days, P < 0.01) in mice. | |
| Target pathways | NA | |
| IC50 | 11.24 μM against MDA-MB-231 | |
| Potency | Our data provide evidence for the suppression of mammary adenocarcinoma by DET with several mechanisms and suggest that DET has potential as a chemopreventive agent for breast cancer. | |
| Cell line/ mice model | MDA-MB-231, MCF-7 | |
| Additional information | 1) Quantitative proteome analysis of TNBC cell-secreted exosomes showed that DET and DETD-35 attenuated the expression of proteins related to cell migration, cell adhesion, and angiogenesis. 2)DET and DETD-35 induced reactive oxygen species (ROS) which caused structural damage and dysfunction of mitochondria and increased cytosolic calcium level, subsequently evoking exosome release from the cancer cells. | |
| PubChem ID | 6325056 | |
| Additional PMIDs | 24963325 28706483 20105176 28915644 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:202958-1 | |
| Safety | NA |