| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-564 | |
| Phytochemical name or plant extracts | Dendrophthoe pentandra extract | |
| PMID | 34264566 | |
| Literature evidence | The combinations of paclitaxel-NPDP significantly inhibit proliferation of cells (P<0.001) and it is able to induce G2/M cell cycle arrest (P<0.001). | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Extract nanoparticle | |
| Source of phytochemicals or plant Extracts | Dendrophthoe pentandra | |
| Geographical availability | Assam, Bangladesh, Borneo, Cambodia, China South-Central, China Southeast, Jawa, Laos, Lesser Sunda Is., Malaya, Myanmar, Nepal, Philippines, Sumatera, Thailand, Vietnam | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | TUBB3, MAP4 | |
| Gene or Protein evidence | These results indicate that the combination of NPDP nanoparticles could reduce the expressions of TUBB3 and MAP4. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | The combinations of paclitaxel-NPDP significantly inhibit proliferation of cells (P<0.001) and it is able to induce G2/M cell cycle arrest (P<0.001). The combination of paclitaxel-NPDP significantly decreases the expressions of TUBB3 (P<0.001) and MAP4 (P<0.001) in MCF-7 cells. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | MCF-7 cells are cultured and divided into six groups: group 1 was a negative control (without paclitaxel or NPDP), group 2 was treated with paclitaxel alone, groups 3-5 were treated with NPDP (2, 4, and 8 mg/mL, respectively) and group 6 was treated only by 8 mg/mL of chitosan-NPDP nanoparticles. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:548340-1 | |
| Safety | NA |