| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-79 | |
| Phytochemical name or plant extracts | Demethylzeylasterone | |
| PMID | 11678653 | |
| Literature evidence | This is the first report of topoisomerase II inhibitory activity in a celastroloid. | |
| IUPAC name | (2R,4aS,6aR,6aS,14aS,14bR)-10,11-dihydroxy-2,4a,6a,6a,14a-pentamethyl-8-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2,9-dicarboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Kokoona zeylanica | |
| Geographical availability | India, Sri Lanka | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Topo II alpha | |
| Gene or Protein evidence | In a study to evaluate celastroloids as potential anticancer agents, demethylzeylasterone (5), a 6-oxophenolic triterpenoid from Kokoona zeylanica, was found to be an inhibitor of the enzyme topoisomerase IIalpha (IC(50) = 17.6 microM). | |
| Target pathways | NA | |
| IC50 | 12.5 μM against MCF-7 | |
| Potency | Demethylzeylasterone selectively inhibits the growth of the breast cancer cell line MCF-7 (IC(50) = 12.5 microM) without inhibiting the growth of non-small cell lung cancer (NCI-H460) and CNS glioma (SF-268) cell lines. | |
| Cell line/ mice model | MCF-7 | |
| Additional information | NA | |
| PubChem ID | 10391130 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:161687-1 | |
| Safety | NA |