| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1979 | |
| Phytochemical name or plant extracts | Demethylzeylasteral (T-96) | |
| PMID | 30729271 | |
| Literature evidence | On the other hand, demethylzeylasteral (T-96) is a natural compound isolated from Tripterygium wilfordii Hook F, which has been reported to have various pharmacological properties including anti-inflammatory and immunosuppressive activities. | |
| IUPAC name | (2R,4aS,6aR,6aS,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,6a,14a-pentamethyl-8-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | |
| Phytochemicals’ class or type of plant extracts | Carbopolycyclic compound | |
| Source of phytochemicals or plant Extracts | Tripterygium wilfordii Hook F | |
| Geographical availability | China South-Central, China Southeast, Myanmar, Taiwan, Tibet, Vietnam | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Vimentin, fibronectin, α-SMA | |
| Gene or Protein evidence | Thus, these results revealed that T-96 downregulates the levels of vimentin, fibronectin, and α-SMA expression through the inhibition of TGF-β signaling pathway in MDAMB-231 cells. | |
| Target pathways | non-canonical TGF-β signaling pathways | |
| IC50 | NA | |
| Potency | These results demonstrate that T-96 inhibited invasion of MDA-MB-231 and 4T1 cells via suppressing the canonical and non-canonical TGF-β signaling pathways. | |
| Cell line/ mice model | MDA-MB-231, 4T1 mouse model | |
| Additional information | T-96 inhibited TGF-β-induced migration and epithelial-mesenchymal transition both in vitro and in vivo. | |
| PubChem ID | 10322911 | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:162908-1 | |
| Safety | NA |