| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1551 | |
| Phytochemical name or plant extracts | Dehydrothyrsiferol | |
| PMID | 10087323 | |
| Literature evidence | Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines | |
| IUPAC name | (1S)-4-[(2R,4aS,6R,8aR)-2-[(2S,5R)-5-bromo-2,6,6-trimethyloxan-2-yl]-4a-methyl-3,4,6,7,8,8a-hexahydro-2H-pyrano[3,2-b]pyran-6-yl]-1-[(2R,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]pent-4-en-1-ol | |
| Phytochemicals’ class or type of plant extracts | Terpenoid | |
| Source of phytochemicals or plant Extracts | Laurencia viridis sp nov | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines | |
| Cell line/ mice model | T47D, ZR-75-1, and Hs578T | |
| Additional information | As the investigated mammary cell lines did not exhibit rhodamine 123 efflux we proved in a P-glycoprotein (Pgp) overexpressing human epidermoid cancer cell line that the marine metabolite does not modulate Pgp mediated drug transport. Therefore, it could be used in Pgp expressing cancer cells without interference. | |
| PubChem ID | 11721258 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |