| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1786 | |
| Phytochemical name or plant extracts | Dehydroeburicoic acid | |
| PMID | 22753732 | |
| Literature evidence | In addition to MAA, methyl antcinate B, dehydroeburicoic acid, and 15α-acetyl-dehydrosulfurenic acid also exhibited significant selective cytotoxic effects to respective cancer cells. | |
| IUPAC name | (2R)-2-[(3S,5R,10S,13R,14R,17R)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid | |
| Phytochemicals’ class or type of plant extracts | Triterpenoid | |
| Source of phytochemicals or plant Extracts | Antrodia camphorata | |
| Geographical availability | Taiwan | |
| Plant parts | NA | |
| Other cancers | Breast cancer, Oral cancer, Epithelioid cancer, Prostate cancer, Ovarian cancer, Cervical cancer, Bone cancer, Stomach cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | Deregulates the PI3K/Akt/mTOR signaling pathway and key cell-cycle mediators, and induces apoptosis | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | KB, TSCCa, GNM, OC-2, and OEC-M1 , Panc-1 , BT-474, PC-3, OVCAR-3, HeLa, and U2OS, ER+ T47D | |
| Additional information | Exhibits significant selective cytotoxic effects on the cell lines Inhibits tube-like structures of endothelial cells, blood vessel branching and microvessel formation ex vivo and in vivo. 3. DeEA exhibited non-cytotoxic effects towards human stomach cancer NUGC-3 cells , here it had significant cytotoxic effects on various cancer types, especially on head and neck cancer. Moreover, it has been reported that DeEA induced calcium- and calpain-dependent necrosis but not apoptosis in human U87MG glioblastomas . | |
| PubChem ID | 15250826 | |
| Additional PMIDs | 28160860 | |
| Additional sources of information | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095428/ | |
| Safety | NA |