| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1853 | |
| Phytochemical name or plant extracts | Deacetyl-mycoepoxydiene | |
| PMID | 25661342 | |
| Literature evidence | DM could induce cell cycle arrest at G2/M in MCF-7 cells. | |
| IUPAC name | (2R,3R)-3-hydroxy-2-[(1S,6R,7S,8R)-8-methyl-9-oxabicyclo[4.2.1]nona-2,4-dien-7-yl]-2,3-dihydropyran-6-one | |
| Phytochemicals’ class or type of plant extracts | Novel secondary metabolite | |
| Source of phytochemicals or plant Extracts | Plant endophytic fungi Phomosis sp | |
| Geographical availability | NA | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Bax, Caspase 9, PARP, p21, Bcl-2 | |
| Gene or Protein evidence | Additionally, DM-induced apoptosis was characterized with up-regulating caspase-3, Bax, caspase-9, parp, and p21 while down-regulating Bcl-2 activation. | |
| Target pathways | NA | |
| IC50 | NA | |
| Potency | DM could induce cell cycle arrest at G2/M in MCF-7 cells. | |
| Cell line/ mice model | MCF-7, nude mice with human breast carcinoma xenografts. | |
| Additional information | The results obtained from these in vitro and in vivo models provide new data revealing the potential for DM as a novel microtubule inhibitor. | |
| PubChem ID | 91885623 | |
| Additional PMIDs | NA | |
| Additional sources of information | NA | |
| Safety | NA |