| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-896 | |
| Phytochemical name or plant extracts | Daucus carota oil extract | |
| PMID | 22815230 | |
| Literature evidence | The present study established that DCOE possesses both antioxidant and promising anticancer activities. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Oil extract | |
| Source of phytochemicals or plant Extracts | Daucus carota | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Azores, Baleares, Baltic States, Belarus, Belgium, Bulgaria, Canary Is., Cape Verde, Central European Rus, China South-Central, China Southeast, Corse, Cyprus, Czechoslovakia, Denmark, East Aegean Is., East European Russia, Eritrea, Ethiopia, France, Germany, Great Britain, Greece, Hungary, Iran, Iraq, Ireland, Italy, Kazakhstan, Kirgizstan, Kriti, Krym, Lebanon-Syria, Libya, Madeira, Morocco, Nepal, Netherlands, North Caucasus, Northwest European R, Norway, Pakistan, Palestine, Poland, Portugal, Romania, Sardegna, Sicilia, South European Russi, Spain, Sweden, Switzerland, Tadzhikistan, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Turkmenistan, Ukraine, Uzbekistan, West Himalaya, Yugoslavia | |
| Plant parts | Umbels | |
| Other cancers | Breast cancer, Colon cancer | |
| Target gene or protein | BAX, Bcl-2, Caspase 3, PARP, ERK | |
| Gene or Protein evidence | he increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. Furthermore, treatment of MDA-MB-231 cells with either fraction significantly reduced the level of phosphorylated Erk but did not show any effect on phosphorylated Akt. | |
| Target pathways | Erk pathway | |
| IC50 | The IC50 values for DPPH and FIC assays were 2.1 ± 0.03 mg/ml and 0.43 ± 0.02 mg/ml, respectively. | |
| Potency | The present study established that DCOE possesses both antioxidant and promising anticancer activities. | |
| Cell line/ mice model | MCF-7, MDA-MB-231, HT-29, Caco-2 | |
| Additional information | Also, DCOE demonstrated a significant increase in cell death and decrease in cell proliferation. | |
| PubChem ID | NA | |
| Additional PMIDs | 25300932 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:841063-1 | |
| Safety | NA |