| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1124 | |
| Phytochemical name or plant extracts | Daucosterol linolenate (DLA) | |
| PMID | 32512614 | |
| Literature evidence | Author information: (1)Chongqing Productivity Promotion Center for the Modernization of Chinese Traditional Medicine, School of Pharmaceutical Sciences, Southwest University, Chongqing, China. (2)Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. (3)Oncology Department, Chongqing Beibei District Hospital of Traditional Chinese Medicine, Chongqing, China. (4)Chongqing Engineering Research Centre for Sweet Potato, School of Life Sciences, Southwest University, Chongqing, China. (#)Contributed equally Sweet potato is a functional food with potential antitumor properties, but the bioactive constituents and biological mechanisms remain unclear. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phytosterol | |
| Source of phytochemicals or plant Extracts | Ipomoea batatas | |
| Geographical availability | Belize, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Venezuela | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 3, Caspase 9, PARP-1 , Ki67, VEGF, Bcl-2,Bax, Bcl-xL | |
| Gene or Protein evidence | All treatments activated caspase 3, 9, PARP1 cleavage, down-regulated Ki67, VEGF, BCL-2, BCL-XL, up-regulated BAX expression, and inhibited PI3K/AKT/NF-κB activation in tumor tissues. | |
| Target pathways | Phosphoinositide 3-kinase/protein kinase B pathway. | |
| IC50 | NA | |
| Potency | NA | |
| Cell line/ mice model | MCF-7 xenograft in nude mice, MDA-MB-231, 4T1 | |
| Additional information | DLA, DL, and DP inhibit tumor growth in MCF-7 xenograft nude mice by regulating the homeostasis of gut microbiota, producing SCFAs, and then disturbing the expression of cancer-related proteins. | |
| PubChem ID | NA | |
| Additional PMIDs | 33642013 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1101088-2 | |
| Safety | NA |