| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1216 | |
| Phytochemical name or plant extracts | Daucosterol Linoleate | |
| PMID | 29878766 | |
| Literature evidence | From these results, we can assume that DL is a potential adjuvant therapy for ER-positive breast cancer patients. | |
| IUPAC name | (6-{[1-(5-ethyl-6-methylheptan-2-yl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl]oxy}-3,4,5-trihydroxyoxan-2-yl)methyl (9E,12E)-octadeca-9,12-dienoate | |
| Phytochemicals’ class or type of plant extracts | Steroid | |
| Source of phytochemicals or plant Extracts | Ipomoea batatas | |
| Geographical availability | Belize, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico Gulf, Mexico Northeast, Mexico Southeast, Mexico Southwest, Nicaragua, Panamá, Venezuela | |
| Plant parts | NA | |
| Other cancers | Breast cancer | |
| Target gene or protein | Ki67, VEGF, Bcl-2, PI3K/AKT/NF-kB, XIAP, Bax, Bad | |
| Gene or Protein evidence | All treatments activated caspase 3, 9, PARP1 cleavage, down-regulated Ki67, VEGF, BCL-2, BCL-XL, up-regulated BAX expression, and inhibited PI3K/AKT/NF-κB activation in tumor tissues. DL diminished the expression of Bcl-xl, Bcl-2, and XIAP, while increasing Bax, Bad, and activated caspase-dependent apoptosis in tumor tissues. | |
| Target pathways | Inactivated the upstream Pi3k/Akt/NF-κB pathway. Our findings suggest that DLA suppresses breast tumor growth through inactivating the phosphoinositide 3-kinase/protein kinase B pathway. | |
| IC50 | 53.27 ± 9.02 µg/mL against MCF-7 | |
| Potency | In conclusion, this study delineated a pathway that DL blocks the progression of breast cancer by inducing apoptosis and inhibiting lung metastasis through inactivating the Pi3k/Akt/NF-κB pathway. The results provided substantiation for the potential use of DL for the adjuvant therapy in ER-positive breast cancer patients. However, further clinical trials are needed to support our viewpoint. | |
| Cell line/ mice model | MDA-MB-231, MCF-7, 4T1, MCF-7 xenograft nude mice | |
| Additional information | Experiments with MCF-7 xenograft in nude mice further confirmed that DLA inhibited tumor growth dose-dependently. After DLA treatment, the expressions of B-cell lymphoma 2 and vascular endothelial growth factor were decreased and that of cleaved caspase 3 was increased as compared to the TC group. DLA also down-regulated the expression of phosphoinositide 3-kinase/protein kinase B and repressed insulin-induced phosphoinositide 3-kinase/protein kinase B activation. | |
| PubChem ID | NA | |
| Additional PMIDs | 33642013 32512614 | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:1101088-2 | |
| Safety | Moreover, DL had no cytotoxicity in human nontumorigenic breast epithelial MCF-10A cells |