| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-1720 | |
| Phytochemical name or plant extracts | Datura stramonium (DS) and Datura inoxia (DI) ethyl acetate leaf extract | |
| PMID | 32552791 | |
| Literature evidence | Comprehensive screening divulged the tremendous potential of selected species as potent source of natural anticancer agents in a variety of cancers particularly leukemia. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Ethyl acetate extract | |
| Source of phytochemicals or plant Extracts | Datura stramonium | |
| Geographical availability | Datura stramonium - Bahamas, Belize, Bermuda, Costa Rica, Cuba, Dominican Republic, El Salvador, Guatemala, Haiti, Honduras, Jamaica, Mexico Central, Mexico Gulf, Mexico Northeast, Mexico Northwest, Mexico Southeast, Mexico Southwest, Netherlands Antilles, Nicaragua, Panamá, Texas, Turks-Caicos Is. Datura inoxia - Colombia, Costa Rica, Honduras, Mexico Central, Mexico Northeast, Mexico Southeast, Mexico Southwest, Panamá, Texas | |
| Plant parts | Leaves | |
| Other cancers | Breast cancer | |
| Target gene or protein | NA | |
| Gene or Protein evidence | NA | |
| Target pathways | NA | |
| IC50 | 1.56 ± 0.16 μg/ml against MDA-MB 231 2.45 ± 0.04 μg/ml against MCF-7 | |
| Potency | DIL-EA exhibited greater cytotoxicity against PC-3, MDA-MB 231 and MCF-7 cell lines (IC50 < 3 μg/ml in each case) as well as higher protein kinase inhibitory action (MIC: 25 μg/disc) compared to DSL-EA. | |
| Cell line/ mice model | PC-3, MDA-MB 231 and MCF-7 | |
| Additional information | This selective action of used extracts is extremely beneficial in targeting cancerous cells while sparing the normal ones. | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:314738-2 https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:314739-2 | |
| Safety | Both extracts exhibited significant brine shrimp cytotoxicity (LC50 < 12.5 μg/ml). These findings showed that the chosen extracts were safe up to the highest dose of 2000 mg/kg and additional pharmacological studies can be safely undertaken within the specified range. |