| Properties | Information | |
|---|---|---|
| PhytoCAT-ID | PhytoCAT-217 | |
| Phytochemical name or plant extracts | Dark sweet cherries | |
| PMID | 32924599 | |
| Literature evidence | In conclusion, DSC phenolics inhibited MDA-MB-453 breast cancer cells by targeting cell signaling pathways that induce apoptosis and suppress cell invasion, with ACN showing enhanced chemopreventive activities. | |
| IUPAC name | NA | |
| Phytochemicals’ class or type of plant extracts | Phenolic extract | |
| Source of phytochemicals or plant Extracts | Prunus avium | |
| Geographical availability | Afghanistan, Albania, Algeria, Austria, Belarus, Belgium, Bulgaria, Corse, Cyprus, Czechoslovakia, Denmark, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Krym, Libya, Morocco, Netherlands, North Caucasus, Norway, Poland, Portugal, Romania, Sardegna, Sicilia, Spain, Sweden, Switzerland, Transcaucasus, Tunisia, Turkey, Turkey-in-Europe, Ukraine, Yugoslavia | |
| Plant parts | Whole plant | |
| Other cancers | Breast cancer | |
| Target gene or protein | Caspase 8, Bax, Bcl-2, PARP-1 | |
| Gene or Protein evidence | The extrinsic and intrinsic apoptotic pathways were also activated by DSC phenolics via caspase-8 cleavage and increased Bax/Bcl-2 ratio, with ACN exhibiting significant activation and stronger PARP-1 cleavage. | |
| Target pathways | ERK1/2-Akt and MAPK intrinsic mitochondrial pathways | |
| IC50 | NA | |
| Potency | DSC phenolics inhibited MDA-MB-453 breast cancer cells by targeting cell signaling pathways that induce apoptosis and suppress cell invasion, with ACN showing enhanced chemopreventive activities. | |
| Cell line/ mice model | MDA-MB-453 | |
| Additional information | NA | |
| PubChem ID | NA | |
| Additional PMIDs | NA | |
| Additional sources of information | https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:30093848-2 | |
| Safety | NA |